Interactomics

Interactomics is a fusion science of biology, informatics, and engineering. It uses various experimental techniques to determine molecular and cellular level interactions to produce usually a large quantity of information. Bioinformatics is used to analyze the data and information to produce more meaningful information and knowledge.
Interactomics is a discipline of bioinformatics and biology that deals with studying both the interactions and the consequences of those interactions between and among proteins, and other molecules within a cell. These interactions are called the Interactome. Interactomics aims to compare networks of interaction between and within species to see how the traits of such networks are varied and conserved. Interactomics is an example of "top-down" systems biology, which takes an overhead view of a system. Large sets of genome-wide data are collected, and correlations between different molecules are inferred. From the data new hypotheses are formulated about feedbacks between these molecules. These hypotheses can then be tested by new experiments . Through the study of the interaction of all of the molecules in a cell the field looks to gain a deeper understanding of genome function and evolution than just examining an individual genome in isolation. Interactomics goes beyond cellular proteomics in that it not only attempts to characterize the interaction between proteins, but between all molecules in the cell.

Further information:

1. Kiemer, L; G Cesareni (2007). "Comparative interactomics: comparing apples and pears?". TRENDS in Biochemistry 25: 448–454
2. Bruggeman, F J; H V Westerhoff (2006). "The nature of systems biology". TRENDS in Microbiology 15: 45–50
3. Krogan, NJ; et al. (2006). "Global landscape of protein complexes in the yeast Saccharomyeses Cerivisiae ". Nature 440: 637–643
4. Article  Interactomics from Wikipedia, the Free Enciclopedia. Available under the license Creative Commons Attribution-Share Alike.

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