Metabolomics

Metabolomics describes the analysis and identification of the complement of small molecules (metabolites) in biological systems such as mammals, plants, animals, and microbes. Metabolomics involves the rapid, high throughput characterization of the small molecule metabolites found in an organism. Since the metabolome is closely tied to the genotype of an organism, its physiology and its environment, metabolomics offers a unique opportunity to look at genotype-phenotype as well as genotype-envirotype relationships. Metabolomics is increasingly being used in a variety of health applications including pharmacology, pre-clinical drug trials, toxicology, transplant monitoring, newborn screening and clinical chemistry. However, a key limitation to metabolomics is the fact that the human metabolome is not at all well characterized.

Further information 

1. Beecher C.W.W. (2003) In: Metabolic profiling: Its role in biomarker discovery and gene function analysis (G.George and RG.Harrigan eds.) Springer, New York, pp. 311-335.
2. Weckwerth W. (2003) Annu. Rev. Plant. Biol., 54, 669–689.
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4. Novotny et al J Chromatog B (2008) 866:26-47
5. Griffiths, W.J. and Wang, Y. (2009) Chem Soc Rev 38:1882-96
6. Morrow Jr., Ph.D., K. John (1 April 2010). "Mass Spec Central to Metabolomics". Genetic Engineering & Biotechnology News 30 (7): p. 1. Archived from the original on 28 June 2010.
7. Crockford DJ, Maher AD, Ahmadi KR, et al. (September 2008). "1H NMR and UPLC-MS(E) statistical heterospectroscopy: characterization of drug metabolites (xenometabolome) in epidemiological studies". Anal. Chem. 80 (18): 6835–44.
8. Машко С.В. и др. Использование метаболической регуляции для оптимизации экспрессии генов – новое направление развитие биотехнологии XXI века. // Биотехнология №4 –2002. – С. 3-14.
9. Meynial-Salles, I., Cervin, M.A., Soucaille, P. “New Tool for Metabolic Pathway Engineering in Escherichia coli: One-Step Method To Modulate Expression of Chromosomal Genes”. // Appl. & Enviroment. Microbiol. 71 – 2005. – 2140-2144.
10. Bongaerts, J., Krämer, M., Müller, U., Raeven, L., Wubbolts, M. “Metabolic Engineering for Microbial Production of Aromatic Amino Acids and Derived Compounds” – Minireview. // Metabolic Engineering 3 – 2001. – Р. 289-300.
11. Лохов П.Г., Арчаков А.И. Масс-спектрометрические методы в метаболомике // Биомедицинская Химия, 2008 том 54, вып. 5, с. 497-511.
12. Статья Metabolomics из Wikipedia, свободной энциклопедии. Доступно под лицензией Wikipedia
13. Статья Метаболомика из Wikipedia, свободной энциклопедии. Доступно под лицензией Wikipedia

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