Proteomics

Proteomics is the large-scale study of proteins, particularly their structures and functions. Proteins are vital parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The term "proteomics" was first coined in 1997 to make an analogy with genomics, the study of the genes. The word "proteome" is a blend of "protein" and "genome", and was coined by Marc Wilkins in 1994. The proteome is the entire complement of proteins, including the modifications made to a particular set of proteins, produced by an organism or system. This will vary with time and distinct requirements, or stresses, that a cell or organism undergoes. Key subjects covered in proteomic research include: identification and interpretation of protein sequence information, a new developments in mass spectrometry that will advance future research high-throughput recombinant DNA cloning methods used to systematically clone all of the open reading frames of an organism into plasmid vectors for large scale protein expression and functional studies such as protein-protein interactions with the two-hybrid system protein structure an overview of large-scale experimental attempts to determine the three-dimensional structures of representative sets of proteins computational approaches to determining the three-dimensional structure of proteins.

Further information

1. Anderson NL, Anderson NG (1998). "Proteome and proteomics: new technologies, new concepts, and new words". Electrophoresis 19 (11): 1853–61.
2. Blackstock WP, Weir MP (1999). "Proteomics: quantitative and physical mapping of cellular proteins". Trends Biotechnol. 17 (3): 121–7.
3. Wilkins MR, Williams KL, Appel RD, Hochstrasser DF (1997). Proteome Research: New Frontiers in Functional Genomics (Principles and Practice). Berlin: Springer.
4. Simon Rogers, Mark Girolami, Walter Kolch, Katrina M. Waters, Tao Liu, Brian Thrall and H. Steven Wiley (2008). "Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models". Bioinformatics 24 (24): 2894–2900.
5. Vikas Dhingraa, Mukta Gupta, Tracy Andacht and Zhen F. Fu (2005). "New frontiers in proteomics research: A perspective". International Journal of Pharmaceutics 299 (1–2): 1–18.
6. Rzhevsky D.I., Zhokhov S.S., Babichenko I.I., Goleva A.V., Goncharenko E.N., Baizhumanov A.A., Murashev A.N., Lipkin V.M., Kostanyan I.A. (2005). HLDF-6 peptide affects behavioral reactions and organism functions dependent on androgen hormones in normal and castrated male mice. Regul. Pept. 127 (1-3), 111–21.
7. Archana Belle, Amos Tanay, Ledion Bitincka, Ron Shamir and Erin K. O’Shea (2006). "Quantification of protein half-lives in the budding yeast proteome". PNAS 103 (35): 13004–13009.
8. Арчаков А. И. Что за геномикой? – Протеомика. //Вопр. мед. химии, 2000. Т. 46, № 4. С. 335–343.
9. Замятнин А.А. Блистающий мир белков и пептидов. //Биология. 2002. № 25–26. P. 8–13.
10. Статья Proteomics из Wikipedia, свободной энциклопедии. Доступно под лицензией Creative Commons Attribution-Share Alike .

Back to Russian